A gel combination of clindamycin phosphate 1.2% and benzoyl peroxide 3.75% was significantly more effective against acne vulgaris than a vehicle gel, and lesion count reductions were greater in women, based on data from a study of nearly 500 adults with moderate to severe acne.
In the post hoc analysis, the mean percent change in both inflammatory and noninflammatory lesions from baseline to 12 weeks was greater among women than men. The findings were published by Dr. Julie C. Harper, a dermatologist in Birmingham, Ala., in the April issue of the Journal of Drugs in Dermatology. However, the results were limited by the inability to determine the contributions of the individual ingredients, she noted.
Read the article here (J. Drugs Dermatol. 2015;14:381-4).